Day of the Triffids plot! I forget if I've mentioned this to anyone before.
A METEOR SHOWER [temporarily] blinds everyone who sees it. Then GIANT WALKING PLANTS invade and the residents have to fight them off while blind. Basic invasion plot, really, but it'd force everyone to use different senses and find ways to improvise.
ETA: This could also be a way for non-fighty characters to be heavily involved in a fighty plot. If, say, Francine was the only one left with vision, she'd be invaluable to the fighty folk
Re: More Specific Brainstorming
A METEOR SHOWER [temporarily] blinds everyone who sees it. Then GIANT WALKING PLANTS invade and the residents have to fight them off while blind. Basic invasion plot, really, but it'd force everyone to use different senses and find ways to improvise.
ETA: This could also be a way for non-fighty characters to be heavily involved in a fighty plot. If, say, Francine was the only one left with vision, she'd be invaluable to the fighty folk